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This is consistent with glutamate being a marker for neurodegeneration

Owens, R

Lorenz RC, Gleich T, Buchert R, Schlagenhauf F, Khn S, Gallinat J

Cell debris was removed by centrifugation at 4,400 g at 4 C for 30 min, and the clarified cell lysate was directly used for biocatalytic reactions

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The sample was limited to males to avoid the influence of menstrual cyclical changes of hormones on reaction times 48 and due to known differences in biochemical responses of the brains of males and females to caffeine, based on animal models of ADHD 49