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The remaining 125 participants received 9% saline (placebo) as group A, two doses of 25 g rSARS-CoV-2 without adjuvant Matrix-M1 as group B, two doses of 5 g rSARS-CoV-2 + 50 g Matrix-M1 as group C, two doses of 25 g rSARS-CoV-2 + 50 g Matrix-M1 as group D, and one dose of 25 g rSARS-CoV-2 + 50 g Matrix-M1 as group E, at a ratio of 1:1:1:1:1, respectively

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