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doi: 10.3390/cells9122648 34 DhanasekaranRDeutzmannAMahauad-FernandezWDHansenASGouwAMFelsherDW

PNMT is a cytosolic enzyme that is present in many tissues throughout the body, with particularly high concentration in the adrenal medulla, adrenergic neurons in the amygdala and retina and the left atrium of the heart (Haavik et al., 2008)

References References Selective and membranepermeable small molecule inhibitors of NNMT Roles of Nicotinamide NMethyltransferase in Obesity and Type 2 Diabetes Nicotinamide Nmethyltransferase inhibition mimics and boosts exercisemediated improvements in muscle function in aged mice Reduced calorie diet combined with NNMT inhibition establishes a healthier gut microbiome in obese mice Kraus et al

Chronic high fructose intake reduces serum 1,25 (OH)2D3 levels in calcium-sufficient rodents

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