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The Broad Institute Connectivity Map analyzed 1,309 bioactive molecules and selected GHK-Cu as the single best agent for reversing metastatic colon cancer gene signatures

Different subtypes are expressed in different tissues, and p38 is most abundant in inflammatory cells

Clonal HeLa cell lines expressing Cas9 (with a hygromycin selection cassette) or an HRE-GFP ODD reporter construct were previously generated by the laboratory 22