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Within this evidence framework, combined prescriptions (aerobic/HIIT plus resistance) are more likely than single-modality programs to produce a closed-loop gainfront-end ignition (AMPKULK1, PINK1/PRKN) together with back-end flux consolidation (TFEBCLEAR, lysosomal function) ( 5 Mechanisms by which exercise-regulated mitophagy ameliorates PD pathology Parkinsons disease (PD) is a neurodegenerative disorder whose pathogenesis involves multiple pathological processes, including oxidative stress, -synuclein (-syn) aggregation, neuroinflammation, dysregulation of calcium homeostasis, and ferroptosis (Nakahira et al., 2015

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