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Research has shown that restoring MECP2 expression solely in GABAergic neurons of male mice can significantly improve multiple disease features in a Rett syndrome mouse model, including ataxia, apraxia, and social abnormalities (76)

Treatment of these small-cell lung cancer cells with the NMDAR1 antagonists dizocilpine (MK-801) and memantine impaired cell viability, whereas treatment with the NMDAR2 antagonists ifenprodil and Ro25-6981inhibited cell growth (71)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 271.A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes