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By performing co-culture experiments between wild-type or UBE2I KD cancer cells and CCA-derived cancer-associated fibroblasts (CAFs), human endothelial cells or monocytes, we have unveiled the impact of SUMOylation in the crosstalk between CCA cells and the TME

Primary kidney cells and IMR90 cells were treated with DMF, a potent inducer of succination-dependent oxidative stress and their proliferation was assessed

In endocytosis, internalized membrane proteins can be directed to lysosomes or retrieved into tubulo-vesicular carriers for recyclingeither directly back to the PM (fast recycling), indirectly via the endocytic recycling endosomes (slow recycling), or, in some cases, back to the secretory pathway 2

Biosensors 10 , 79 (2020)

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In a casecontrol study, exenatide treatment over a 12month period led to a 15% improvement in UPDRS scores in earlystage PD patients, alongside a reduction in CSF neuroinflammatory markers [256]