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Quality of Life and Performance Status From a Substudy Conducted Within a Prospective Phase 3 Randomized Trial of Concurrent Accelerated Radiation Plus Cisplatin With or Without Cetuximab for Locally Advanced Head and Neck Carcinoma: NRG Oncology Radiation Therapy Oncology Group 0522

Measures of cumulative exposure, such as AUC, provide a means to individualize treatment

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Proper titration, which requires accurate reconstitution, helps manage these by allowing gradual dose escalation rather than sudden jumps

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