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One of the main reasons why it's strongly recommended to divide the doses evenly throughout the day is to reduce the chances of experiencing adverse effects such as: Paraesthesia (some users may actually like this effect) Rapid changes in pH Higher excretion rates [1] This brings us back to the tingling sensation discussed in the introduction, and it's known as paresthesia

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2000 [cited 2023 Jun 2];28(1):2730

Neurology 92 , e1145e1156 (2019)