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10.1093/ijnp/pyu031 3 AbrialE.EtievantA.BtryC.ScarnaH.LucasG.HaddjeriN.et al (2013)

Response to Excessive and Reduced Stimulation of Receptors: Excessive Receptor Activation can result in desensitization or down regulation

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Other very helpful supplements to induce UGT activity include resveratrol, curcumin, astaxanthin, and quercetin (9)