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This metaanalysis found a positive association between PD and insecticides (sRR = 1.50, 95% CI, 1.072.11), and herbicides (sRR = 1.40, 95% C, 1.081.81), but not with fungicides (sRR = 0.99, 95% CI, 0.711.40) (van der Mark et al., 2012), in agreement with Brown et al

Mechanistically, icaritin is an inhibitory-B Kinase alpha (IKK-) inhibitor, which inhibits the NF-B signaling pathway by blocking IKK complex formation, and further dose-dependently downregulates PD-L1 [216]