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As individuals age, the cells gradually enter to a state called cellular senescence in which the cell division is permanently abstained and the pattern of gene expression and normal cell function is altered (Hubackova et al., 2012

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however, until now, we have been without any official guidance on management

In one study, FI-SARS-CoV reduced viraemia and protected against lung pathology in rhesus macaques 124 , whereas in another study macaques given FI-SARS-CoV developed macrophage and lymphocytic infiltrates and alveolar oedema with fibrin deposition after challenge, indicating the difficulties of establishing consistent NHP models 125

The present research study was part to the Xinjiang Uyghur Autonomous Region, Department of Science and Technology and Xinjiang Production and Construction Crop Science and Technology Bureau jointly fund the Tianshan Talents Science and Technology Program Innovation Leading Talents Training Project (No: 2023TSYCLJ0057), Tarim University, Alar, China