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doi: 10.4049/jimmunol.176.11.6794 12 BhattacharyyaA.ChattopadhyayR.MitraS.CroweS

Humira is one of several treatment options for autoimmune conditions

Schultz ST, Klonoff-Cohen HS, Wingard DL, Akshoomoff NA, Macera CA, Ji M

With this respect the development of novel therapeutic approaches targeting ROS will require to identify and dampen the main sources of deleterious ROS relevant for a specific disease, without altering the vital physiological sources of ROS and their downstream signaling pathways

By lowering intracellular ROS and inhibiting NF-B-dependent transcriptional priming of NLRP3, Nrf2 activity functionally lowers inflammasome formation in sterile neuroinflammatory conditions such as PD