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Although reference ranges vary between laboratories, evidence suggests that disease risk begins to increase well before homocysteine reaches the traditional upper limit of 15 mol/L

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A potential exception is KRAS-G13D colorectal cancer, where some studies have reported modest responses, although this remains controversial and is not widely adopted in clinical practice.7375 Targeting mediators of RAS activation, including SOS1 and PTPN11, represents another promising avenue

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