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2276-C ALLO-LCA, A BILE ACID DERIVATIVE WITH DUAL ACTIVITY ON GPBAR1 AND RORT, ALLEVIATES NASH-INDUCED LIVER FIBROSIS Michele Biagioli 1 , Cristina Di Giorgio 1 , Martina Bordoni 1 , Silvia Marchian 1 , Carmen Massa 1 , Rachele Bellini 1 , Ginevra Urbani 1 , Eleonora Distrutti 2 , Angela Zampella 3 and Stefano Fiorucci 1 , (1)University of Perugia, (2)Azienda Ospedaliera Di Perugia, (3)University of Naples, Federico II Background: NAFLD is due to the pathological accumulation of lipids in hepatocytes

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Leuk Res 31:79

However, the concentration of these inhibitors required to trigger even partial hyphal inhibition was found to be above the established safety threshold of these drugs, which calls for further exploration to find anti-hyphal compounds with lower systemic toxicity [173]

MTF cartilage grafts, extended spreader grafts, extended alar contour grafts, a columellar strut, and mastoid fascia were used to not only improve her breathing but to help provide long-term stability and structure to the nose, and maintain its appearance long-term

Second, the population exposed to low, medium, and high Hg was likely to be heterogeneous