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Targeting 6-phosphogluconate dehydrogenase in the oxidative PPP sensitizes leukemia cells to antimalarial agent dihydroartemisinin

Acsl4 dictates ferroptosis sensitivity by shaping cellular lipid composition

6.2.5 Implication for MFH These genetic axes motivate hypotheses that MFH actives could: (i) support mitophagy/mitochondrial quality control, (ii) reinforce endogenous redox buffering (e.g., Nrf2-GPX4), and (iii) dampen inflammation linked to mitochondrial stress