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Route of administration changes the result: supervised subcutaneous injection of 503A compounded GHK-Cu produces systemic and targeted effects that topical serums cannot replicate

1,13 Moreover, inhibiting either component of system Xc (i.e., SLC7A11 or SLC3A2) induces ferroptosis by disrupting cystine uptake, thereby limiting GSH synthesis

Released inflammatory mediators not only directly damage dopaminergic neurons but also compromise the integrity of the bloodbrain barrier

Therefore, the role of Nrf2 in DKD should be further discussed

DA deprivation significantly caused the activation and proliferative changes of astroglial fibrillary acidic protein-positive cells in the striatum (Zhu et al., 2020)

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