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Table 1 indicates different mechanisms of OP-induced neurotoxicity

Physical Symptoms of Kratom Withdrawal : Muscle aches Restless legs Chills, sweating Nausea, cramps, diarrhea Insomnia, fatigue Psychological Symptoms of Kratom Withdrawal : Anxiety Depression Intense cravings Social withdrawal Irritability and mood swings Restlessness or agitation Difficulty concentrating (brain fog) Insomnia or disrupted sleep patterns Relapse often stems from a desire to end the discomfort, not to chase a high

Why This Combination Stands Out

doi: 10.3389/fcimb.2021.657775 Received 24 January 2021 Accepted 11 May 2021 Published 03 June 2021 Volume 11 - 2021 Edited by Diego Luis Costa, University of So Paulo, Brazil Reviewed by Maria Regina DImprio Lima, University of So Paulo, Brazil

Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction

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