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N.et al (1994)

The two-receptor approach is studied because GHRH and GHS-R1a signaling activate complementary but distinct intracellular pathways GHRHR primarily through Gs/cAMP/PKA, GHS-R1a primarily through Gq/PLC/IP3/Ca making the dual-agonist approach a useful research tool for studying somatotrope cell biology comprehensively

There is also a high degree of heterogeneity among participants of the analyzed studies

doi: 10.1089/ars.2018.7502 76 HsuLIHsiehFIWangYHLaiTSWuMMChenCJet al

These include the aging population, patients with growth hormone deficiency, and those who suffer from amyotrophic lateral sclerosis and myotonic dystrophy 111