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Additionally, TSA can induce the expression of the major ING1 isoform p33, a type II tumor suppressor involved in histone modification and DNA damage response, and ING1 has been shown to participate in glioma-induced angiogenesis, serving as a cross-node that links acetylation-regulated angiogenesis to apoptosis through the FADD/caspase 3 signaling pathway (Tamannai et al., 2010)

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Re-addition of NFT resulted in Nrf2 re-accumulation, GCLC and glutathione synthesis followed this trend in cells treated with 20 M NFT