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Joensuu JT, Aaltonen KJ, Aronen P, et al

Some studies found the polymorphic allele related to less toxicity, better therapy response and more survival but others found the opposite regarding to toxicity (Rednam et al., 2013)

N-acetylcysteine (NAC), a glutathione precursor, reportedly acts as an anti-oxidant factor by targeting ROS 30 , and anti-oxidant effects of NAC in animal models exhibiting pathologies associated with ROS have been reported 31,32,33