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There is no study without limitations

This review will focus on recent findings describing how different pathological states compromise BBB integrity, discuss current potential therapeutic approaches that have been explored for improving BBB integrity and slowing neurodegenerative disease pathologies, and the recent findings in microbial mediated modulation of the BBB

, a plant in the Camelliaceae family, and is used as a drink with great nutritional, health and medicinal value (13, 14)

The Sod2 mice (C57BL/6 J) were generated by Lebovitz [26], and purchased from the Jackson Laboratory

Moreover, the timing of cognitive impairment coincides with the early plaque formation in transgenic mice, instead of decades after plaque development in human AD [152, 157, 158]

Primers used were as follows: Gpx4 (forward: 5-AGT ACA GGG GTT TCG TGT GC-3