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Endurance or aerobic training, high-intensity interval training (HIIT), and supplementation with curcumin or pomegranate result in the downregulation of oncogenic microRNAs such as miR-21, miR-155, and angiomiR-126, while simultaneously promoting the upregulation of tumor suppressor proteins including P53 and Bax, thereby facilitating the process of apoptosis

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Rebuzzi AG, Schiavoni G, Lanza GA, et al

By controlling mitochondrial biogenesis and respiration, both PGC-1 and p53 contribute to the cellular nutrient-sensing pathway