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Mitochondrial thioredoxin-2/peroxiredoxin-3 system functions in parallel with mitochondrial GSH system in protection against oxidative stress

Glutathione helps regulate this response by modulating the activity of immune cells and cytokines

Although it has been reported that disease phenotype only presents in tissues such as muscle and brain at high mutant loads (typically above 90%) for most pathogenic mutations, the MTND5 gene mutation can result in diseased phenotype at low mutant loads even below 50% (Kirby et al., 2003)

This indicates that viral infection of a particular cell might have pleiotropic effects on non-infected bystander cells, making them more permissive to viral replication