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It is a mechanical explanation that complements the pharmacological one

IGF-I modulates the activity of orexin neurons Since IGF-I significantly increases the number of orexin neurons expressing c-fos, a marker of cell activation, we determined regulation of the activity of orexinergic neurons by IGF-I using electrophysiological recordings

Fukushi, H

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[DOI] [PubMed] [Google Scholar] [117].Kayagaki N, Stowe IB, Lee BL, et al