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Moreover, the lipid bilayer safeguards the encapsulated Vitamin C from environmental degradation and limits hepatic first-pass metabolism, which may lead to improved bioavailability over nonliposomal forms (Lee, 2020

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Generally, iron accumulation induces OS, bringing about the increase of ROS levels and the imbalance of antioxidant balance and infiltrating pro-inflammatory mediators that further amplify cerebral inflammatory responses, which aggravate neuronal damage during reperfusion (Jin et al., 2013

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These agents interact with hydrophobic pockets in SLC7A11, and the chlorophenoxy group binds to TM1a, TM6b, and TM7, while the quinazolinol group binds to TM5 and TM8 [207]

405 In the presence of inflammation, IL-6 induces an upregulation of C5a receptor on endothelial cells, thereby augmenting their sensitivity to C5a and subsequently increasing vascular permeability