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Despite the encouraging results, this study has several limitations that warrant further investigation

However, the exact signaling pathway involved has yet to be clarified in future studies

Petzinger E

Both drugs possess clinically favourable pharmacokinetic and pharmacodynamic profiles: higher affinity to MOP than morphine [247, 248], high brain uptake [249, 250], long duration of action [11]

Thus, del11q, associated with the low expression of ATM, inhibits glucose and glutamine metabolism pathways

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