bacterial and host-derived glutathione are required to activate prfa Host is for Rickettsia parkeri properly septate, avoid ubiquitylation, survive in macrophages Allosteric GSH binding primes PrfA

Allosteric GSH binding primes PrfA for DNA binding. (A and B) Download Scientific Diagram Multiple regulatory check points control prfA expression and protein Download Scientific Diagram Diverse roles of low molecular weight thiol GSH in Francisella's virulence, location sensing and GSH stealing from host ScienceDirect Listeria monocytogenes requires phosphotransferase systems to facilitate intracellular growth and virulence PMC Glutathione Provides a Source of Cysteine Essential for Intracellular Multiplication of Francisella tularensis PLOS Pathogens Listeria monocytogenes utilizes glutathione and limited inorganic sulfur compounds as sources of essential cysteine Infection and Immunity

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