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Therefore, the use of KD in individuals with PD can raise concerns, as their nutritional status is a significant factor affecting lifespan, and people with PD are already at a high risk of malnutrition

If its use is required, a reduced continuous infusion rate should be advised for infants with GA under 32 weeks, as their immature metabolic pathways slow drug clearance and place them at higher risk of accumulating excessive plasma concentrations during prolonged sedation or analgesic therapy (272)

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In a 26-week rat oral toxicity study, AOD-9604 produced dose-dependent changes in serum osteocalcin (a bone-turnover marker) at week 13, with the direction reversing by week 26

SNX-0723, identified through scaffold-based screening, selectively binds the ATP-binding pocket of HSP90 and demonstrates improved brain penetration, reducing mutant huntingtin aggregation in PD and HD models

Hemin: a Possible Cause of Oxidative Stress in Blood Circulation of beta-Thalassemia/Hemoglobin E Disease