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We've already noted that glutathione is made up of three amino acids: cysteine, glutamic acid, and glycine

Another aspect of GST catalysis by necessity involves transfer of a negative charge en route to, and as part of, the transition state (as the nucleophilic GSH thiolate attacks the electrophilic substrate)

Received: 27/05/2017 Introduction Multidrug resistance (MDR) is a unique type of resistance by which cancer cells develop cross resistance to a broad spectrum of anticancer agents [1]