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10.1016/j.neuropharm.2012.09.015 98 SandireddyR.YerraV

A clear scientific overview of the broader ghrelin/GHS system is available in this NIH/PMC review (Veldhuis & Roelfsema, 2010)

13 , e1318 (2023)

They achieve this multifunctionality by expression of a diverse set of activation receptors, including those that directly recognize pathogens and opsonized targets, and by their ability to store and release preformed cytotoxic mediators that participate in host defense, to produce a variety of de novo pleotropic mediators and cytokines, and to interact directly and indirectly with diverse cell types, including adaptive and innate immunocytes and structural cells