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This is primarily mediated by aquaporin water channels (for example, AQP4) and inwardly rectifying K + channels such as Kir4.1, which are often colocalized at astrocytic endfeet adjacent to blood vessels

That structural gap is one reason the evidence base looks the way it does

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Effect of linagliptin vs placebo on major cardiovascular events in adults with type 2 diabetes and high cardiovascular and renal risk: the CARMELINA randomized clinical trial

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