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6.1 Targeting the synergy between -synuclein aggregation and ferroptosis Iron overload accelerates the formation of toxic -syn oligomers, while aberrant -syn expression disrupts iron metabolism and GSH synthesis, thereby creating a vicious cycle that enhances neuronal susceptibility to ferroptosis (Chen et al., 2025)

Isolation of extracellular vesicles by ultracentrifugation

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Notably, combination therapy maintains a safety profile comparable to Western monotherapy (Zheng et al., 2024)