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However, therapeutic strategies for ALS remain limited

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Upon hormone binding, these receptors move into the nucleus and alter the expression of genes involved in immune regulation and maintaining tissue integrity [172]

As a humanized monoclonal antibody, bevacizumab works by binding directly to the VEGF protein, eliminating VEGFs ability to interact with VEGF receptors and exert its angiogenic effects.Citation 51 Aflibercept is another common anti-VEGF drug that is advantageous as has a high binding affinity for VEGF