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Quick Take (TLDR) Mostly animal and in vitro data plus multiple very small uncontrolled human reports (knee pain case series n=16, interstitial cystitis pilot n=12, 2subject IV infusion) and no randomized controlled trials or published human pharmacokinetic profiles

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The contents of the letter should include an explanation of the diagnosis that requires the vitamin or supplement, says Nielsen

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B12 injections are one way to ensure that people who dont get enough of the vitamin in their diet can still maintain their health