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Oxidation is basically caused by highly oxidizing substances such as ROS and reactive nitrogen radicals (RNS).The production of these substances can not only fight against invading pathogens, but also oxidize or damage DNA, proteins and lipids, inducing gene mutations, protein denaturation and lipid peroxidation (127)

When there is a deficiency in the MMR machinery, these errors cannot be corrected, resulting in microsatellites that are different in size and MSI [19]

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