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Long term low to moderate-intensity exercise enhances the expression of antioxidant enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GPX), while reducing the activity of oxidases including NADPH oxidase and xanthine oxidase, inhibiting expression of inflammatory cytokines, and enhancing the release of angiogenic factors such as vascular endothelial growth factor (VEGF), stromal cell-derived factor-1 (SDF-1), HIF-1, and matrix metalloproteinase-9 (MMP-9) (Wang et al., 2019

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The partial epigenetic reprogramming gene therapy Life Biosciences will use rejuvenates cells, rather than turning them into stem cells, and extends mouse lifespan

10.3390/antiox11061160 2 AbbasK.RizwaniG

Mielke MM Article: EXPERIMENTAL GERONTOLOGY

For the low- and high-dose treatment groups, 10-fold and 30-fold the human-equivalent doses were administered, respectively