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A second step should include specific questionnaires (i.e., STOP BANG for sleep apnea, Pittsburgh Sleep Questionnaire Index (PSQI) for SDs, Epworth Sleepiness Scale for EDS, Morningness-Eveningness Questionnaire to identify chronotype), followed by specific sleep-medicine tools based on clinical suspicion, such as home sleep apnoea testing for SBDs/OSAS, polysomnography for hypersomnia and multiple sleep latency test (MSLT) for narcolepsy and other central hypersomnias [126]

The immune status drives capacity to release or uptake iron but tumor-secreted cytokines (e.g

K.KumarR.GangulyR.RanaH

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Oxidative microenvironment exerts an opposite regulatory effect on cytokine production by Th1 and Th2 cells

Gill et al., 2013)