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Upon completion, mice were released from the tube, and temperature recording continued for an additional 30 min while they moved freely within the plastic cage (24 17 12 cm)

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In vitro experiments further disclosed the inhibitory effect of sUA on the monocyte Toll-like receptor (TLR) signaling pathway, which in turn reduces the migration capability of classical monocytes ( Macrophages Macrophages in most tissues have diverse functions, including initiating immune and inflammatory responses toward pathogens, maintaining tissue homeostasis, and contributing to tissue repair and remodeling ( Figure 2 )