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Moreover, curcumin has demonstrated efficacy in the treatment of acute lung injury and fatal acute respiratory distress syndrome caused by human coronaviruses in multiple trials (306)

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Nuclear enrichment of glycogen synthase kinase 3 (GSK3) has been demonstrated to exert a substantial repression effect on the transcription and expression of genes implicated in de novo serine synthesis, including SHMT2 and MTHFD2 [1]