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KLOW 80 KLOW 80 is a blend of four experimental peptides : BPC-157 TB-500 (thymosin beta-4 fragment) KPV GHK-Cu None are FDA-approved

They revealed that cells with down-regulated GPX4 expression were more susceptible to ferroptosis, while the overexpression of GPX4 inhibits ferroptosis (Yang et al., 2014)

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2.6 P53 The p53 protein serves a critical role in the cellular response to iron overload, maintaining a balanced state of iron by finely regulating the transcriptional activity of specific genes ( Moreover, p53 is not only involved in iron homeostasis regulation but also enhances the cellular antioxidant defense system by activating the expression of a series of antioxidant enzymes, including GSTs, HO-1, and superoxide dismutase (SOD) ( When the skin is exposed to harmful environmental factors, such as ultraviolet rays, the p53 protein promptly activates its protective mechanism ( Moreover, p53 plays a pivotal role in combating skin aging