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In parallel, glutamate metabolism is disrupted, and excess glutamate contributes to motor neuron degeneration through excitotoxicity, calcium overload, and modulation of astrocytic reactivity 14

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doi: 10.1002/jlb.63.1.94 [DOI] [PubMed] [Google Scholar] 78.Klotman ME, Chang TL

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Particularly noteworthy is that FOXO4 influences not only lifespan but also the quality of aging through its interaction with the protein p53commonly referred to as the "guardian of the genome." This interaction regulates whether cells remain in a senescent, metabolically inactive state or undergo programmed cell death (apoptosis)