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Peer review Peer review information Nature Reviews Microbiology thanks Ellen Blaak, Hauke Smidt and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

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For instance, considering the occurrence of maculopathy and progressive retinal degeneration among patients with clbC and, to some extent, patients with cblD, interestingly, such conditions do not manifest in patients with mutations in the other genes associated with VitB12 metabolism [50]

They are grouped into the Betaherpesvirinae as unique members of the Proboscivirus genus 7

FIGURE 3 shows a Flow Diagram showing distribution of subjects at each stage of the study described in Example 1