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Luo Y, Bai XY, Zhang L, Hu QQ, Zhang N, Cheng JZ, et al

The staining is performed with the fluorescent dyes 2,7-dichlorodihydrofluorescein diacetate (H 2 DCFH-DA), hydroethidine (HE), monobromobimane (MBB) and TO-PRO-3

In vivo study: After treated with LW231 for 42 days in the AAV-HBV mice, the mean declines in HBV DNA was 0.2, 2.2 and 2.3 logs, in HBsAg was 0.3, 0.8, 0.5 logs, in HBeAg was 0.08, 1.1, 0.7 logs comparison to pretreatment levels in mice dosed with 50, 100 and 200 mg/kg LW231, respectively

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[238] [239] [240] [241] In the United States, an emergency use authorization (EUA) is "a mechanism to facilitate the availability and use of medical countermeasures, including vaccines, during public health emergencies, such as the current COVID-19 pandemic", according to the Food and Drug Administration (FDA)