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doi: 10.1242/jcs.093849

13,14,15 Restoring levels of these in the body can help improve concentration and mental clarity

Two Longterm Phase 3 Studies of Enarodustat ( JTZ 951) in Japanese Anemic Patients with Chronic Kidney Disease Not on Dialysis or on Maintenance Hemodialysis: SYMPHONY NDLong and HDLong Studies

Peak fractions from anion-exchange chromatography (IEX) were concentrated using centrifugal concentrators (Amicon, 30 kDa molecular weight cut-off (MWCO)) and polished by size exclusion chromatography (SEC, HiLoad 16/600 Supderdex 200 pg, Cytiva) in CRBN SEC buffer (50 mM HEPES/NaOH pH 7.4, 150 mM NaCl, 1 mM TCEP)

This combination strategy effectively reduces cell viability and induces apoptosis, thereby further corroborating the feasibility of integrating metabolic intervention with conventional chemotherapy (112)