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Additionally, PAHs, such as benzo[a]pyrene, are oxidized in the liver by CYP1A1 and CYP1B1 to form epoxides, which are subsequently hydrolyzed by epoxide hydrolase (EH) into highly reactive diol epoxides (e.g., BPDE), thereby driving the molecular mechanisms of bladder cancer (Thier et al., 2003

Talanta 41 , 211215 (1994)

4.5 Senolytic supplements: fisetin & quercetin 4.5.1 Fisetin Fisetin is a flavonoid found in various fruits and vegetables, such as strawberries, apples, onions, and cucumbers

4E-BPs require non-canonical 4E-binding motifs and a lateral surface of eIF4E to repress translation

While this could indicate that flux through the PPP is necessary to compensate for oxidative processes downstream of glycolysis, it is also possible that optimal PPP flux is needed during the initial steps of activation