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One notable dual-substrate NNMT inhibitor is Yuanhuadine, which is isolated from the flower buds of the traditional Chinese medicine Daphne genkwa

doi: 10.1002/advs.202505359 251 SuWGaoYJiaXChenXWuJWenYet al

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Antioxid Redox Signal 15(2):551589 Devoz PP, Reis MD, Gomes WR, Maraslis FT, Ribeiro DL, Antunes LG, Batista BL, Grotto D, Reis RM Jr, FB, (2021) Adaptive epigenetic response of glutathione (GSH)-related genes against lead (Pb)-induced toxicity, in individuals chronically exposed to the metal