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Oxidative stress then accelerates the aggregation of -synuclein which subsequently binds and sequesters available GSH, creating a destructive feedback loop of protein misfolding and antioxidant loss (Hoepken et al., 2007)

Potential Treatment Strategies Understanding the involvement of TMAO in various disease conditions has resulted in active research and analyses to identify potential therapeutic strategies to reduce TMAO levels in the serum

In addition, we performed a follow-up (median time: 984 d) after the completeness of the intervention, where the long-term effect of vitamin B-6 and GSH supplementation on clinical outcomes could be investigated