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C, Chastang, R, Birembaut, P., and Gillery, P., In vivo stimulation of connective tissue accumulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ in rat experimental wounds

Sci Rep 6: 21180

Senescent macrophages exhibit a significant increase in Pro-inflammatory and immunomodulatory cytokines and chemokines (including TNF-, IL-6, and IL-1), diminished autophagic function, impaired antiviral capabilities, and downregulation of glycolysis and mitochondrial oxidative phosphorylation, ultimately leading to a state of energy depletion 36

Disclosure of interest: The authors declare no conflict of interests relevant to this research or publication of this abstract

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