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Besides diminished RBC production, CKD is linked to metabolic and structural changes in circulating erythrocytes, such as heightened oxidative stress, compromised membrane protein integrity, and decreased deformability

Interestingly, iron-citrate complex efficiently induces DNA strand breaks (Toyokuni and Sagripanti 1993)

For instance, topical applications often require higher concentrations at the site of action compared to injected methods, which bypass first-pass metabolism

It appears that oxidized enzymes of the Calvin-Benson cycle are more likely to be inactivated, while oxidized TBS enzymes seem to be more destabilized (Wittmann et al., 2023)

Similar reductions in MDA levels have been reported in poultry supplemented with ZnO-NPs at a concentration of 60 mg/kg BW, reflecting improved membrane stability and antioxidant efficiency 91